Welcome to the Sondek Lab
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![Last Sondek Lab virtual meeting of 2020](https://www.med.unc.edu/pharm/sondeklab/wp-content/uploads/sites/868/2020/12/group-meeting_2020_2_800x342-300x128.png)
Last (virtual) group meeting of 2020
Structural Biology of Signal Transduction
Our laboratory studies signal transduction systems controlled by heterotrimeric G proteins as well as Ras-related GTPases. The superfamily of GTPases control numerous signaling cascades based upon the regulated binding, hydrolysis, and exchange of guanine nucleotides; GTP-bound GTPases are active in downstream signaling while those bound to GDP are inactive. Mutant GTPases with abnormal GDP/GTP cycling are implicated in numerous human diseases, including cancer. It is our desire to better understand the regulation of heterotrimeric G proteins and Ras-related GTPases at the molecular level with the ultimate goal of using this information to design therapies to correct abnormal signaling mediated by these proteins and thereby treat associated pathologies.
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